Histological Study of Breast in Patients with Fibroadenoma in Correlation with Vitamin D Deficiency

INTRODUCTION: Fibroadenomas are common benign breast tumors comprising 95% of all biopsied breast masses. Vitamin D has a strongly indicated ability to modify the histology of the breast.
Objective: To correlate histological alterations in breast tissue with deficient vitamin D in women clinically diagnosed to have fibroadenoma.
METHODS: Eighty women aged in a range between 25-45 year complaining from breast lump diagnosed as cases of fibroadenoma. Fifty women of them were agreed to undergo surgical excisional biopsy. Blood samples for testing 25(OH) D were collected from them before the operation.Excisional biopsies of the breast lumps were collected and tissue specimens were processed and prepared for examination by light microscope. The demographic data and histological findings were statistically analyzed for comparison between group A and B.
RESULTS: Histological examination of breast tissue from women of group B showed pericanalicular fibroadenoma in 70% of cases with more sever hyperplasia of the epithelial lining and showed intracanalicular fibroadenoma in 80% of cases with sever proliferation of stromal cells compressing the duct to be slit like spaces and lobulations expanded beyond the surrounding fibroblastic stroma in addition to sever adipose tissue deposition in 84% of cases and sever hyalinization of stroma.
DISCUSSION AND CONCLUSION: Conclusion: The study concludes a significant association of the histological appearance of breast fibroadenoma with deficiency of vitamin D indicated by suppressing the epithelial and stromal proliferation of breast lesions thus vitamin D supplement might arrest the progression of fibroadenoma towards breast cancer.